Extended Data Fig. 4: Role of cooperativity and toxic conversion.
From: Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
a, Best global fit of experimental Ca2+-influx data to secondary oligomer kinetic model with reaction order γ = 3 (Supplementary Note 1, Eq. 8). b, Misfit of permeation measurements to a kinetic model that assumes slow toxic conversion of oligomers generated initially through secondary nucleation (Supplementary Note 1, Eq. 9). Theoretical predictions were generated assuming an arbitrary timescale for conversion comparable to that of the aggregation reaction (τ = 0.5 h in this case).
