Extended Data Fig. 5: The chaperone DNAJB6 inhibits primary nucleation of Aβ42 aggregation.
From: Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
a, Monomeric Aβ42 was incubated at a concentration of 2 μM in the presence of 20 μM ThT at 37 °C under quiescent conditions in the absence (black) and presence (blue: 0.1%, green: 0.25%, orange: and 0.5% relative to monomeric Aβ42) of DNAJB6. b, Global fits to the kinetic traces. c, Relative primary nucleation rate kn. d, Drawing of the microscopic events of Aβ42 aggregation in the presence of DNAJB6 that inhibits primary nucleation.
