Extended Data Fig. 6: Comparison of yeast and human Rev7-RIR complexes.
From: Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis
a, Sequence alignment of yeast and human RBM1 and RBM2 regions of Rev3. Conserved prolines within RBM1 and RBM2 are highlighted in green. Also, highlighted are the conserved residues among the yeast and human homologs within the RIR region. b, Structural comparison of the yeast and human RBM1 and RBM2. Individual structures of human Rev7 with RBM1 peptide (hRev7:RBM1; PDB ID: 3ABD) and RBM2 peptide (hRev7:RBM2; PDB ID: 6BC8) are compared to the corresponding sub-regions (yRev7A:RBM1; yRev7B:RBM2) in the yeast Polζ holoenzyme. The protein residues involved in the interactions are highlighted in green and the RIR is shown in brown. The interactions of Rev7A and Rev7B with the RIR segment connecting RBM1 and RBM2 (yRev7A:yRev7B:RIRint) is also depicted.
