Fig. 2: Cryo-EM structures reveal differential stabilization of the S-protein in the mutant ectodomain constructs.
From: Controlling the SARS-CoV-2 spike glycoprotein conformation
a, The S-protein spike, highlighting the two regions of interest for structure and computation-based design (PDB 6VXX). b, The rS2d RBD-to-S2 locked structure displaying only the all-RBD-down state map. c, The u1S2q SD1-to-S2 mutated structure displaying the all-RBD-down state, the 1-RBD up state and the 2-RBD up state. The percentage shown in orange is the sum of particles found in either the 1- or 2-RBD up state. Each protomer in each map is colored differently, with resolutions for these listed below. Red asterisks indicate up-state RBDs.
