Extended Data Fig. 1: MERS-CoV S, SARS-CoV S and SARS-CoV-2 S pseudotyped virus neutralization.
Neutralization assays of MLV (a-c) or VSV (d–f) particles pseudotyped with (a,d) MERS-CoV S (a, Data shown for 1 representative experiment with 3 replicates (n = 2 independent experiments); d, Data shown for 1 representative experiment with 5 replicates (n = 2 independent experiments)) (b,e) SARS-CoV S (b, Data shown for 1 representative experiment with 3 replicates (n = 2 independent experiments); e, Data shown for 1 representative experiment with 2 replicates (n = 2 independent experiments)) and (c,f) SARS-CoV-2 S (c, Data shown for 1 representative experiment with 2 replicates (n = 2 independent experiments); f, Data shown for 1 representative experiment with 2 replicates (n = 2 independent experiments)) were performed in the presence of the indicated concentration of B6 mAb. Data are presented as mean values ± SD and were evaluated using a non-linear sigmoidal regression model with variable Hill slope. Experiments were performed with two independent mAb and pseudotyped virus preparations.
