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ENZYME MECHANISMS

Cryo-EM structures tell a tale of two telomerases

Nature Structural & Molecular Biology volume 28, pages 457–459 (2021)Cite this article

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New atomic-resolution structures provide detailed insights into the molecular mechanism of telomerase, ushering in a new era of rational drug design to target telomerase in human genetic disorders and cancer.

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Fig. 1: Generalized cartoon schematic of the telomerase active site.
Fig. 2: Comparison of Tetrahymena and human telomerase ribonucleoprotein structural organization.

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Authors and Affiliations

  1. Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA, USA

    Nicholas M. Forino

  2. Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, USA

    Jendrik Hentschel & Michael D. Stone

  3. Center for Molecular Biology of RNA, University of California, Santa Cruz, Santa Cruz, CA, USA

    Michael D. Stone

Authors
  1. Nicholas M. Forino
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  2. Jendrik Hentschel
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  3. Michael D. Stone
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Correspondence to Michael D. Stone.

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The authors declare no competing interests.

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Forino, N.M., Hentschel, J. & Stone, M.D. Cryo-EM structures tell a tale of two telomerases. Nat Struct Mol Biol 28, 457–459 (2021). https://doi.org/10.1038/s41594-021-00611-8

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