Extended Data Fig. 9: Sequence alignment of mouse TRPV channels.
From: Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel
α helices and β strands are depicted above the sequences as cylinders and arrows, respectively. The * symbols indicate residues in the ARD and linker domain that interact with residues in the C-terminus (¥ symbols). Red rectangular outlines denote regions involved in the interaction of the C-terminus with the ARD and linker domain, including residues conserved in thermo-TRPVs, and the AR5 and linker domain loops, which are present in thermo-TRPVs and absent in TRPV5–6. The location of the selectivity filter (S.F.) is indicated by a red box. Identical residues are colored red and highlighted in light pink. Positions of the previously identified mutations in TRPV3 that are critical for thermal sensitivity are highlighted in dark pink.
