Extended Data Fig. 4: The number of extrusion complexes tunes the relative frequency of singlet- to adjoining-doublet interactions.
From: DNA-loop-extruding SMC complexes can traverse one another in vivo
a, In the experimental Hi-C map for the −59o−94o strain after 60 min of SirA expression, the frequency of singlet contacts to adjoining doublet contacts is close to 1:1. This is only achieved when the number of extrusion complexes is >40 and for sufficiently high bypassing rates. b, A parameter sweep over the number of extruders and the bypassing rate. The best matched parameter combination is shown boxed in red. For a description of how we obtained the overall best parameters, see Methods and Supplementary Figs. 4-7.
