Extended Data Fig. 8: FLCN-10 peptide is cell-permeable and inhibits LDHA.
From: The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect
a) Fluorescence microscopy of HEK293 cells treated with 1 µM Rhodamine B-labeled peptides from Fig. 2b. Peptides that are resident after two hours treatment have been denoted with a red number and box. NT = No treatment. Scale bar = 10 µM. b) HEK293 cells treated with peptides from Extended Data Fig. 8a. Bar chart represents fold change of pTyr10-LDHA normalized to NT. Data shown as mean ± s.d. (n=3).
