Extended Data Fig. 1: The tumor suppressor FLCN mediated binding and inhibition of LDHA. | Nature Structural & Molecular Biology

Extended Data Fig. 1: The tumor suppressor FLCN mediated binding and inhibition of LDHA.

From: The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect

Extended Data Fig. 1

a) Gene Ontology term analysis of FLCN proteomic data using Panther v15.0 (pantherdb.org). b) LDHA-FLAG IP from HEK293 cells immunoblotted with anti-FLCN antibody. c) Titration of FLCN-FLAG expression in HEK293 cells immunoblotted with anti-pTyr10-LDHA antibody. d) Titration of siRNA targeting FLCN in HEK293 cells immunoblotted with anti-pTyr10-LDHA antibody. Bar chart contains densitometry of pTyr10-LDHA:FLCN ratio. Unpaired Student’s t-test, (p < 2.9x10−10, n=3). Data shown as mean ± s.d.

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