Fig. 2: Single-particle cryo-EM analysis of nanostructure-tagged FSE.

a, Secondary structure of the FSE-ATP-TTR3 as determined by SHAPE chemical mapping, with key structural elements indicated in different colors. b, Cryo-EM map of the FSE-ATP-TTR3 at a low contour level, oriented as in a. c, ATP-TTR 3 model (PDB ID 6WLK) docked into the FSE-ATP-TTR3 map. d, FSE map from Fig. 1c, green, docked into the extra density of the FSE-ATP-TTR3 map. e, Comparison between the FSE map and the extra density of the FSE-ATP-TTR3 map.