Extended Data Fig. 5: Triplex forming lncRNAs govern long-range interactions.
From: Three-dimensional genome organization via triplex-forming RNAs
(a-f) Diagonal correlations coefficient (dCCC) along the first 10 Mb between the experimental Hi-C contact map and the contact maps derived from the ensemble of the 3D models generated using lncRNAs with triplex potential from cluster 4: (A) ENST00000547963.1, (B) ENST0000043436.1, (C) ENST00000449111.1, (D) ENST00000561611.2, (E) ENST00000540866.2, and (F) ENST00000421202.1 co-TrTS hotspots for each of the 23 chromosomes (grey) and genome-wide average (blue). Vertical red bar marks 250 kb, which is the median length of convergent CTCF loops61. (g-i) Diagonal correlations coefficient (dCCC) along the first 10 Mb between the experimental Hi-C contact map and the contact maps derived from the ensemble of 3D models generated using CTCF enriched genomic loci (orange), ENST00000541775.1 co-TrTS hotspots (light blue), and CTCF & ENST00000541775.1 enriched genomic loci (yellow) for all (G) metacentric, (H) submetacentric, and (I) acrocentric chromosomes. Chromosomes are classified according to the standard Denver classification112.
