Extended Data Fig. 10: Buried mutations in the TRRAP module. | Nature Structural & Molecular Biology

Extended Data Fig. 10: Buried mutations in the TRRAP module.

From: Structure of the human SAGA coactivator complex

Extended Data Fig. 10

a. Overview of TRRAP (as in Fig. 5a), with the rectangle indicating the location of mutations. b. Magnified view of the region showing how the mutations of the two buried glycine residues (G1110W and G1158R) in two neighboring helices are not compatible with bulky sidechain residues. A translucent surface representation is shown with a cartoon model of the TRRAP HEAT repeat domain. C∝ atoms are shown as spheres. Buried residues are shown in orange and surface accessible residues are shown in red (as in Fig. 5d).

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