Fig. 2: Organization of the core and integration of the SPL module. | Nature Structural & Molecular Biology

Fig. 2: Organization of the core and integration of the SPL module.

From: Structure of the human SAGA coactivator complex

Fig. 2

a, Atomic model of hSAGA core. b, Schematic comparison of the histone-fold core organization in hSAGA with the nucleosome. Histone-fold dimers are grouped in boxes, colored by hSAGA subunits (above/below). Corresponding histones are indicated on the side, as well as the contact with the TAF5L WD40 propeller and the potential interaction with TBP below/above. c, Schematic of the relative locations of the distorted histone-fold octamer helices in the hSAGA core and in the nucleosome. d, The (concave) surface of the TAF6L HEAT domain tethers the SPL module in hSAGA (translucent EM contoured at 6.1σ). The SUPT20H NTD latches the TAF5L NTD in place (a close-up on the right). e, In ySAGA, the Taf5 NTD is rotated −59° and occupies the corresponding Taf6 HEAT domain surface (PDB 6T9K). The location of the HAT modules in d and e is indicated by translucent blue ovals and location of the depicted regions in the context of the complete complexes are outlined at the top right.

Back to article page