Fig. 4: Structure of Pol I–RRN3 and Pol I OC. | Nature Structural & Molecular Biology

Fig. 4: Structure of Pol I–RRN3 and Pol I OC.

From: Cryo-EM structures of human RNA polymerase I

Fig. 4

a,b, Pol I–RRN3 (a) and Pol I OC (b). Cryo-EM density for RPA12 and DNA (in the Pol I OC) or newly built subunits (RRN3 in the Pol I–RRN3) is shown as a transparent red, yellow and blue surfaces. c, Differences in the cleft width between the three human Pol I structures. The two modules which move with respect to each other are colored in red (upper clamp and stalk) and blue (core and heterodimer). Nucleic acids are colored in black. The distance was measured from backbone to backbone of RPA1-L341 (clamp core) to RPA2-I396 (protrusion) and is shown with a black line.

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