Extended Data Fig. 10: Details of the loop C-terminal to the P-helix in the CNBD.
From: The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods
a, Structural alignment of CNGA1, CNGB1, TAX-4 in closed state (PDB: 6WEJ), HCN1 in closed state (PDB: 5U6O), and SthK (PDB: 6CJQ). The region of the CNBD is shown, with emphasis on the loop that follows the P-helix. b, Details of the density map at the loop connecting the C-helix and the coiled-coiled region in one of the CNGA1 subunits. K554 and D608 are indicated as possible electrostatic interaction c, Sequence alignment of the loop region among CNG subunits (Bos taurus) and other CNG channels. d, The last C-terminal125 residues of the indicated sequences were used as input for DeepCoil for calculating the propensity of the C-terminus to form a coiled-coil.
