Fig. 6: The deposition of H3K9 methylation acts in parallel with a proposed structural role of MET-2 in transcriptional repression. | Nature Structural & Molecular Biology

Fig. 6: The deposition of H3K9 methylation acts in parallel with a proposed structural role of MET-2 in transcriptional repression.

From: SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity

Fig. 6

The primary function of the SETDB1-like enzyme, MET-2, is to mediate H3K9 methylation (1). Its loss leads to extensive gene and repeat derepression. The concentration of MET-2, LIN-65 and ARLE-14 into nuclear foci requires LIN-65 and represses transcription by H3K9me-independent inhibition of histone acetylation in parallel to ensuring efficient H3K9 methylation (2). ARLE-14 stabilizes MET-2 foci at chromatin redundantly with H3K9me. HATs, histone acetyl transferases; KDMs, histone demethylases; TFs, transcription factors.

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