Extended Data Fig. 8: Sequence alignment of the GPI binding site.
From: Structure of human glycosylphosphatidylinositol transamidase
Analysis of amino acid sequences of PIGU and PIGT homologous. HsPIGU and HsPIGT is from Homo sapiens (Uniprot ID: Q9H490 and Q969N2); MmPIGU-MmPIGT, Mus musculus (Q8K358 and Q8BXQ2); DrPIGU-DrPIGT, Danio rerio (F1RES7 and E9QH65); BdPIGU-BdPIGT, Bactrocera dorsalis (A0A6I9VB87 and A0A034WF00); CePIGU-CePIGT, Caenorhabditis elegans (Q22672 and Q19518); ScPIGU-ScPIGT, Saccharomyces cerevisiae (P41733 and P38875); AtPIGU-AtPIGT, Arabidopsis thaliana (F4I1Z0 and Q949U5); AfPIGU-AfPIGT, Aspergillus fumigatus (A0A0J5PDP8 and Q4WMR2); DdPIGU-DdPIGT, Dictyostelium discoideum (Q54T45 and B0G182). Secondary structures are marked above the alignment. Red triangles indicate residues that are involved in binding of the GPI molecule.
