Extended Data Fig. 3: DOPEGAL modification at Tau K353 is dependent on NE.
From: Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation
Tau P301S/DBH + /- and Tau P301S/DBH-/- mice of 3 months and 9 months old were examined for DOPEGAL modification and phosphorylation of Tau in the LC by immunofluorescence staining. A. Representative images of DBH (green), Tau K353-DOPEGAL (red), and DAPI (blue), AT8 (green), Tau K353-DOPEGAL (red), and DAPI (blue) staining in LC sections of Tau P301S/DBH + /- and Tau P301S/DBH-/- mice. Scale bar = 100 μm. B. Quantification of Tau K353-DOPEGAL/AT8 + cells. Data are shown as mean ± SEM. n = 6 per group. Two-way ANOVA with Sidak’s multiple comparison.
