Extended Data Fig. 3: Relative dimerization properties of 1G, 2G, 3G transcripts.
From: Short- and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging
log2(kdimer) values of the 1G, 2G, and 3G transcript variants compared to the mean of the 1G, 2G and 3G transcripts for (a) high salt uncapped transcripts (b) low salt uncapped transcripts (c) high salt capped transcripts (d) low salt capped transcripts. In all conditions, regions within SL1 are more important for dimerization in 3G compared to 1G samples. In low salt conditions, the 3G variant had increased dependence on regions outside of SL1. Capped and uncapped RNAs show very similar profiles, with the exception of a region in polyA in high salt buffer, which was more important for dimerization in the 1G sample compared to 3G.
