Extended Data Fig. 3: Interface between subunit C and the central rotor in complete V1.
From: Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation
Subunit C (colored by sequence conservation) rotates toward the central rotor subunits F and D (gray) upon dissociation of V1 from VO. There is minimal sequence conservation on the surface of subunit C that interacts with the central rotor in the complete V1 complex. However, in the complete V1 complex subunit C is positioned to block rotation of the rotor subcomplex and prevent rotation from State 2 to State 3.
