Extended Data Fig. 6: Cryo-EM density at the (S)-(+)-ketamine binding site. | Nature Structural & Molecular Biology

Extended Data Fig. 6: Cryo-EM density at the (S)-(+)-ketamine binding site.

From: Structural insights into binding of therapeutic channel blockers in NMDA receptors

Extended Data Fig. 6

a, Zoom-in views of the cryo-EM density (mesh) fitted with the (S)-(+)-ketamine molecule (cyan sticks) in Pose-3. b, Cryo-EM density of human GluN1a-2A NMDARs (PDBID:7EU7 and EMD:31308, upper panel) complexed to (S)-(+)-ketamine (salmon sticks) and human GluN1a-GluN2B NMDARs (PDBID:7EU8 and EMD:31309, lower panel) complexed with (S)-(+)-ketamine (orange sticks).

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