Extended Data Fig. 8: Single-particle analysis on memantine-bound GluN1a-2B NMDARs.
From: Structural insights into binding of therapeutic channel blockers in NMDA receptors
a, A representative EM micrograph, 2D classes, and the 3D classification/refinement workflow. The scale bar represents 34.9 nm. b, The masked (Blue) and unmasked (Red) Fourier shell correlation (FSC) curves of two half maps (Left) and map vs model (Right). c, Zoom-in views of the gate and the pore-forming region fitted with the molecular model. d, The local resolution estimation calculated by ResMap.
