Extended Data Fig. 9: Potency measurement of channel blockers on GluN1a-2B NMDAR.
From: Structural insights into binding of therapeutic channel blockers in NMDA receptors
a-d, Dose-responses of PCP (panel a), S-(+)-ketamine (panel b), memantine (panel c), and Mg2+ (panel d) for wildtype (black circle), GluN1a-V644A (red circle), GluN2B-N615Q (blue triangle), GluN2B-L645A (blue square), and GluN2B-T646S (blue circle) channels recorded on cRNA injected Xenopus oocytes by TEVC. Data points represent the means ± s.d. e, A list of IC50 values, Hill coefficients (nH) calculated based on the dose-response curves. The statistical analysis was done by two-tail Student t-test (*** p < 0.001, ** 0.001 < p < 0.01, * 0.01 < p < 0.05, n.s. not significant. The IC50 values were estimated from independent dose-response recordings from at least four independent oocytes (n).
