Extended Data Fig. 8: The effects of small molecules on KRT8 phase separation.
KRT8 samples were maintained at 37 °C at time point 0, then cooled to 4 °C, leading to ThT phase separations. At 50 µM KRT8 concentration, addition of demeclocycline HCl (10 µM) or the known anti-amyloid compound EGCG (10 µM) reduces ThT signal. Experiment performed with n = 3 replicates. Error bars represent ± SD. Data for graph is available as source data.
