Table 2 Sequence comparison of KRT81–90 with alpha-synuclein

From: Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies

Protein

Sequence

Alpha-synuclein

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA

KRT81–90

SIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQ

  1. The head domain of KRT8 has an enrichment of glycine and serine residues. Additionally, it has a hydrophobic region (highlighted in red) that resembles the amyloidogenic core of alpha-synuclein, known as the NACore (highlighted in red).
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