Extended Data Fig. 9: 3D variability analysis of the four different states of GYS1 and the unique component of the inhibited like Glc6P bound state. | Nature Structural & Molecular Biology

Extended Data Fig. 9: 3D variability analysis of the four different states of GYS1 and the unique component of the inhibited like Glc6P bound state.

From: Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate

Extended Data Fig. 9

a, 3D variability analysis components of all four states of GYS1 reported in this study. Initial and final frames are shown. The unique component of the inhibited like-state is highlighted by a red asterisk. Most movements are either slight flexing at the tetrameric interface or flexing of the N-terminal Rossman domains. b, Alignment of initial and final frames showing a global expansion from the central helical tetrameric interface. c, Close-up of the frames around the allosteric/G6P binding density. d, Namdinator fitted models into the initial and final frames showing a clear movement of the alpha-helices 13 from both subunits towards the regulatory helices.

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