Fig. 4: Substrate-threading mechanism of Drg1.
From: Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1
a, Superposition of symmetric (blue) and asymmetric (orange) maps of Drg1. b, 3.2-Å asymmetric free Drg1 map (orange) versus particle-bound Drg1 map (gray). c, Substrate translocation (top and side view). Substrate (poly-alanine chain) and Drg1 pore loop residues shown as sticks, and the rest of the hexamer model is shown as surface. d, Unphased pore loop substrate engagement of D1 and D2. The conserved tyrosine (Y319 in D1 and Y590 in D2) plus adjacent residues of the pore loop motif are shown.
