Extended Data Fig. 6: Conformational changes during gating of SthK.
From: Anionic lipids unlock the gates of select ion channels in the pacemaker family
(a) One subunit of SthK in the presence of POPA and cAMP is shown (closed state: blue, open state: yellow). Models were aligned to the TMDs. (b) Backbone traces of the TM helices. (c) Backbone traces of the C-linker. (d) Backbone traces of the cyclic nucleotide-binding domain (CNBD). (e) C-linker movements during gating shown in cartoon representation (closed state: blue, open state: yellow). (f) Overlay of SthK in the closed state in the presence of POPA (blue) and POPG (grey, PDB: 6cju). (g) Alignment of only the CNBDs between closed (blue) and open (yellow) SthK. (h) Overlay of the CNBD of SthK in the open state (yellow) with the x-ray structure of the activated CNBD of SthK (purple, PDB: 4d7t).
