Extended Data Fig. 4: SIVmac239 sequence and structural comparisons.
a, The SIVmac239 trimer aligns well to the CD4-bound SIVmac239 core (PDB: ID 6TYB). The glycan shield shows strong similarity for most glycans available in the core with notable differences at positions 47 and 464 where sequons were not glycosylated in the core and position 88 where the gp41 glycan at position N625 overlaps in space with N88 of the core. b, A sequence alignment of HIV-1 (BG505) and SIV (mac239) are shown with secondary structure shown below. Notable positions are indicated for SOSIP mutations. c, The Cα residue-by-residue distances are shown for HIV-1 and SIVcpz compared to residues of SIVmac239 indicating areas of close structural alignment and highlighting regions that diverge significantly.
