Extended Data Fig. 9: The sequence alignments of P-loops and S6 helices of human NaV channels.
From: Structural basis for NaV1.7 inhibition by pore blockers
Residues that contribute to drug binding were shaded and labeled. Specifically, three NaV1.7 antagonists (XEN907, TC-N1752 and NaV1.7-IN2) and three previously reported anti-arrhythmic drugs (flecainide, PDB code: 6UZ0; propafenone, PDB code: 7FBS; quinidine, PDB code: 6LQA), were represented in different shapes and colors. The interacting residues were labeled with corresponding shapes. Residues interacting with the six blockers within 5 Å are highlighted.
