Extended Data Fig. 7: Modeling of Tom5 and Tom6 bound to the SAMTom40-early intermediate.
From: A multipoint guidance mechanism for β-barrel folding on the SAM complex
a, Structures of Tom5 and Tom6 bound to the SAMTom40-early intermediate (SAMTom40-5-6) modeled by fitting simulation analysis. b, c, Close-up views of Tom6 (b) and Tom5 (c) bound to the SAMTom40-early intermediate. d, Structure of the TOM complex (PDB ID: 6JNF). e, f, Close-up views of Tom6 (e) and Tom5 (f) in the TOM complex. g, Interaction energy of Tom40 with Tom5 and Tom6 in the TOM complex (shown by bars in black). Gray zones represent the residues of Tom40 that are not modeled in the EM structure of the SAMTom40-early intermediate. Purple and blue bars in the upper part of the panel indicate the residues interacting with Tom5 and Tom6, respectively. The estimated total subunit interaction free energy is −139.1 kcal/mol for the SAMTom40-early complex and −197.6 kcal/mol for the TOM complex.
