Extended Data Fig. 9: AFM investigation of huntingtin fibrils.
From: The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity
(a) Fluorescence microscopy (upper panels) and AFM (middle and lower panels) images of 2-day-old fibrils of H46, LLLF-H46 and LKGG-H46. Each fluorescence image corresponds to the average of 150 pictures. (b) AFM images of 5-day-old fibrils of the three H46 variants. White squares indicate the zoom region displayed in panels below. At least 6 fluorescence and AFM images for each H46 variant and time point were extracted from two large fields (8.13μm x 8.13μm). Images displayed in (a) and (b) are representative of the ensemble of them.
