Fig. 1: RNA-free Dis3L2 is preorganized to bind RNA substrates. | Nature Structural & Molecular Biology

Fig. 1: RNA-free Dis3L2 is preorganized to bind RNA substrates.

From: A shape-shifting nuclease unravels structured RNA

Fig. 1

a, Domain compositions of Dis3L2 and the homologous proteins Dis3 and RNase R (green, N-terminal PIN domain; pink, CSD1; orange, CSD2; blue, RNB; purple, S1 domain). b, Side (left) and top or apical (right) views of RNA-free Dis3L2D391N with domain labels. c, Charge distribution of the Dis3L2 surface from a side view (left) and a view of the apical face (right), as calculated using PyMol APBS at an ionic strength of 150 mM (Methods) where kB is the Boltzmann constant, T is the temperature in degrees Kelvin and ec is the unit of charge.

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