Extended Data Fig. 5: G4 motifs are prone to recurrent sequencing errors.

a, Insertions and b, deletions within G4 motifs. X-axis indicates positions within G-runs, or spacers between G-runs. Spacers of 1 nt in length are categorized separately. Y-axis is relative mutation frequency. Data presented as mean values, with error bars indicating 95% binomial confidence intervals. Confidence values derived from n = 76,156 individuals and the dynamic loci count. Blue: no sequencing quality filters, green and yellow: increasingly stringent filters. Arrows indicate magnitude and direction of change for individual trinucleotide mutation frequencies before and after sequencing quality filters. Mutations with large magnitude changes are highlighted in text.