Extended Data Fig. 2: Mutagenesis flanking non-B motifs.
From: Revisiting mutagenesis at non-B DNA motifs in the human genome
X-axes are coordinates relative to central motif (0 position encompasses entire repeat). Y-axes are relative mutation frequency (compared to the gnomAD average, normalized by trinucleotide mutation type). Data presented as mean values, with 95% binomial confidence intervals indicated in transparency. Confidence values derived from n = 76,156 individuals and the dynamic loci count. Blue lines: no sequencing quality filters, green and yellow lines: increasingly stringent filters (‘pass’ indicates gnomAD’s passing quality filter based on a VQSLOD score of −2.774). Left: STR motifs (combined with their respective reverse complements). Right: Other non-B motifs. STRs and Symmetrical motifs exclude the shortest 80% by motif length. G4 motifs (strand-specific) detected under K + conditions. Z-DNA motifs detected using standard definition. See Supplementary Fig. 2a–c and Methods for more details.
