Extended Data Fig. 7: Displacement of waters upon antibiotic binding.
From: Structural conservation of antibiotic interaction with ribosomes
a, View of tetracycline binding site (16S rRNA, grey) in the absence (left panel) and presence of tetracycline (right panel). Waters (spheres) that are displaced upon tetracycline (Tet, blue) binding are colored red. b, View of streptomycin binding site (16S rRNA, grey) in the absence (left panel) and presence of streptomycin (right panel). Waters (spheres) that are displaced upon streptomycin (Str, blue) binding are colored red. c, View of spectinomycin binding site (16S rRNA, grey) in the absence (left panel) and presence of spectinomycin (right panel). Waters (spheres) that are displaced upon spectinomycin (Spc, blue) binding are colored red. d, View of kasugamycin binding site (16S rRNA, grey) in the absence (left panel) and presence of kasugamycin (right panel). Waters (spheres) that are displaced upon kasugamycin (Ksg, blue) binding are colored red. e-h, View of (e) lincomycin, (f) clindamycin, (g) tiamulin and (h) retapamulin binding site (23S rRNA, grey) in the absence (left panel) and presence of the drug (right panel). Waters (spheres) that are displaced upon binding of the antibiotic are colored red. In (a)-(h), waters (spheres) that are stabilized upon drug binding are colored green.
