Fig. 1: Structure of GluA2–γ5–CNIH2 complex. | Nature Structural & Molecular Biology

Fig. 1: Structure of GluA2–γ5–CNIH2 complex.

From: Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2

Fig. 1

a,b, 3D cryo-EM reconstruction of GluA2–γ5–CNIH2ZK-SPD viewed parallel to membrane (a) and intracellularly (b), with density for GluA2 subunits colored yellow (subunits A and C) and blue (subunits B and D), γ5 in dark green, CNIH2 in purple, antagonist ZK and channel blocker SPD in red. c–e, GluA2–γ5–CNIH2ZK-SPD structure viewed parallel to membrane (c, broad face; d, narrow face) or intracellularly (e), with protomers colored similarly to a and b and molecules of ZK and SPD shown as space-filling models. f,g, Structures of auxiliary subunits γ5 and CNIH2, with the secondary structure elements labeled.

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