Extended Data Fig. 2: Comparison of AMPAR-CNIH2 complexes with γ5 and γ8. | Nature Structural & Molecular Biology

Extended Data Fig. 2: Comparison of AMPAR-CNIH2 complexes with γ5 and γ8.

From: Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2

Extended Data Fig. 2

a-c, Structures of GluA2–γ5–CNIH2ZK-SPD (a), GluA1/2–γ8–CNIH2NBQX (b; PDB ID: 7OCE), and their superposition (c) viewed parallel to membrane (top) or extracellularly (bottom), with molecules of ZK, SPD and NBQX shown as space-filling models and relative movement of the LBD layer illustrated by blue arrows. The ATD layer is not shown for clarity.

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