Fig. 4: Comparison of SPD and NASPM binding sites. | Nature Structural & Molecular Biology

Fig. 4: Comparison of SPD and NASPM binding sites.

From: Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2

Fig. 4

a–c, Pore-forming domains in the closed-pore structure of GluA2–γ5–CNIH2ZK-SPD (a) and open-pore structure of GluA2–γ2Glu+CTZ+NASPM (b, PDB ID 6DM1), and their superposition (c). Only two of four subunits (B and D) are shown, with the front and back subunits (A and C) omitted for clarity. Residues lining the pore are shown as stick models. Double arrows in a and b indicate distances between backbone carbonyls of Q586 and G588 that form narrow constrictions in the selectivity filter. Blue arrows in c illustrate narrowing of the selectivity filter in the open-pore compared to closed-pore structures.

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