Extended Data Table 1 Functional characteristics

From: Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2

  1. The values of the deactivation time constant (τDeact), the desensitization time constant (τDes), the ratio of the steady-state current in the continuous presence of Glu and the maximal current amplitudes in the presence of CTZ (ISS/IMax), the recovery from desensitization time constant (τRecDes), the index corresponding to the number of kinetically equivalent rate-determining transitions that contribute to the recovery from desensitization time course (m), the rectification index measured as the ratio of the current amplitudes at +40 mV and −40 mV in the presence of CTZ (I+40mV/I−40mV), the half-maximal inhibitory concentration of perampanel (IC50), and the Hill coefficient (nHill) are presented as means ± SEMs.
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