Fig. 6: A model of SNF2h-mediated chromatin regulation based on results of this study.
From: Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler
SNF2h length-sensing can explain context-specific regulatory functions of ISWI complexes. At high-nucleosome-density repressed regions, SNF2h-containing complexes increase the representation of multiple types of regular, short NRL fibers, presumably to facilitate elimination of cryptic NFRs. At lower-nucleosome-density regions, accessible SNF2h slides nucleosomes to increase the site exposure frequency of cis-regulatory elements (for example, CTCF/Ctcf binding sites).
