Extended Data Fig. 8: Reported AIFM2 mutations in different cancer types.
From: Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation
a. COSMIC database analysis. AIFM2 somatic mutations (heterozygous) are found in cancer patients. Mutations can affect the enzymatic activity of FSP1, such as the proton transfer function (E160, K355), NADH binding (G244), and FAD binding (D285), and may affect the efficacy of FSP1 inhibitors (T327). b. DepMap database analysis. The S6 mutation likely affects FSP1 enzymatic activity via altered myristoylation (consensus motif: MGxxxS). c. Representative sequence data for genomic DNA of AIFM2 1 surrounding G337G/D extracted from SKOV3.
