Extended Data Fig. 7: ChIP-seq analysis to AGO2HA in quiescent B cells. | Nature Structural & Molecular Biology

Extended Data Fig. 7: ChIP-seq analysis to AGO2HA in quiescent B cells.

From: AGO2 silences mobile transposons in the nucleus of quiescent cells

Extended Data Fig. 7

(a) Correlation of normalized read counts across biological replicates mapping to transposable elements (TE) following ChIP-seq with an antibody against HA in Ago2+/+ (left) and Ago2HA/HA (right). Each dot represents a distinct TE. Repeats enriched in Ago2HA/HA compared to Ago2+/+ ChIP-seq are labeled in red. (b) As in (A) but comparing Ago2HA/HA and Ago2+/+ normalized read counts for replicate 1 (left) and 2 (right). (c) Cumulative Distribution Fraction plot for log2(TPM + 1) expression values of repeats with (red) or without (grey) AGO2HA enrichment in ChIP-seq data. TPM, transcript per million. p-value was calculated with a two-sided Kolmogorov–Smirnov test.

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