Extended Data Fig. 6: Structure comparison of CRL3KBTBD2 and CRL3KBTBD2–p85α.
From: Dynamic molecular architecture and substrate recruitment of cullin3–RING E3 ligase CRL3KBTBD2
a, b, Side view and bottom view of CRL3KBTBD2 octamer (a) and hexamer (b). c, d, Side view and bottom view of CRL3KBTBD2 tetramer (c) and CRL3KBTBD2–p85α tetramer (d), showing that CRL3KBTBD2 tetramer contains two dimers forming an angle of ~90°, while CRL3KBTBD2–p85α tetramer contains two dimers forming an angle of ~180°. e, Fitting CRL3KBTBD2–p85α dimer models into CRL3KBTBD2 octamer maps, showing that p85α clashes with the neighboring KBTBD2s. f, Structural comparison of CRL3KBTBD2 octamer (gray) with two neighbor CRL3KBTBD2–p85α dimers (colored), the clashes area is indicated by circle. g, The details of clashes between KBTBD2 (gray) and p85α (colored).
