Extended Data Fig. 8: Cryo-EM maps of CSN in complex with neddylated or non-neddylated CRL3KBTBD2.
From: Dynamic molecular architecture and substrate recruitment of cullin3–RING E3 ligase CRL3KBTBD2
a, Overall Cryo-EM maps of CRL3KBTBD2–CSN containing one whole CSN molecules, and (b) one CSN missing the CSN3/8 density. c, Overall Cryo-EM maps of CRL3Kbtbd2~N8Δ–CSN containing one whole CSN molecules, and (d) one CSN missing the CSN3/8 density. e, Overall Cryo-EM maps of CRL3KBTBD2~N8–CSNH138A containing two CSN molecules (one with the whole CSN and another missing the CSN3/8 density), (f) CRL3KBTBD2~N8–CSNH138A containing one whole CSN and missing the CUL3/RBX1 subunits, and (g) CRL3KBTBD2~N8–CSNH138A containing one CSN missing CSN3/8 subunits and weak density in CUL3/RBX1 subunits. h, Summary of the conformation distribution of each state and the resolution of each structure.
