Extended Data Fig. 9: Structural comparison of CSN in complex with neddylated or non-neddylated CRL3KBTBD2.
From: Dynamic molecular architecture and substrate recruitment of cullin3–RING E3 ligase CRL3KBTBD2
a, Structural comparison of CSN in apo CSN (gray) and CRL3KBTBD2~N8–CSNH138A (colored). b, Comparison of CSN in apo CSN (gray) and CRL3KBTBD2–CSN (colored). c, Comparison of CSN in apo CSN (gray) and CRL3KBTBD2~N8Δ–CSN (colored). d, Comparison of CSN in CRL3KBTBD2~N8Δ–CSN (gray) and CRL3KBTBD2~N8–CSNH138A (colored). e, Comparison of CSN in CRL3KBTBD2–CSN (gray) and CRL3KBTBD2~N8–CSNH138A (colored). f-i, The CSN5/6 heterodimers in apo CSN (f), CRL3KBTBD2~N8–CSNH138A ‘deactivating’ state (g), CRL3KBTBD2~N8Δ–CSN ‘deactivated’ state (h) and CRL3KBTBD2–CSN ‘inhibited’ state (i) are shown in cartoon representation. j, Alignment of RBX1 between different states of CRL3KBTBD2. k, Alignment of CUL3WHB and CUL3WHA subdomains between different states of CRL3KBTBD2. The CUL3WHB structures of different states were displayed at right.
