Fig. 5: Interplay between SPT2 and HIRA histone chaperones.
From: The histone chaperone SPT2 regulates chromatin structure and function in Metazoa
a, spt-2KO-B worms were crossed with hira-1/+ heterozygote worms; the full cross strategy is outlined in Extended Data Fig. 5. The numbers of progeny of hira-1/+;spt-2KO-B worms of each indicated genotypes are shown, together with the percentage of fertile worms. b, Percentage of burst worms or worms showing a protruding vulva (Pvl) phenotype on treatment with hira-1 RNAi, or empty vector RNAi, as indicated. Forty worms were scored per replicate, and three independent replicates of the experiment were performed. c, Venn diagram showing the overlap between upregulated genes in spt-2 null and hira-1 null worms. Hypergeometric test; enrichment: 3.085, P value <10–16.
