Extended Data Fig. 7: iPSC related TFs (MYC, NANOG, KLF4) are significantly enriched in both genomic and naïve sequences. | Nature Structural & Molecular Biology

Extended Data Fig. 7: iPSC related TFs (MYC, NANOG, KLF4) are significantly enriched in both genomic and naïve sequences.

From: Regulatory activity is the default DNA state in eukaryotes

Extended Data Fig. 7

a) The ln(e-values) of each TF in both the genomic (x-axis) and naïve sequences (y-axis) (n = 1065). Master regulators of PSCs (KLF4, NANOG, and MYC) are found to be significantly enriched in both naïve and genomic sequences. SOX2 and POU5F1 can be seen in the upper right-hand corner (non-significant). b) Enrichment ratio for genomic (x-axis) and naïve (y-axis) for the same TFs in (A).

Back to article page