Extended Data Fig. 4: Evolved DNA has less antisense expression, and more expression extremes.
From: Regulatory activity is the default DNA state in eukaryotes
(a, b) Cumulative fractions of base pairs (y-axes) for each RNA-seq read coverage (x-axes), for both naïve and evolved DNA (colours), for (A) the minimum coverage of the two DNA strands or (B) the maximum coverage of the two strands. P-values from a two-sided Kolmogorov-Smirnov test, using only every 1000th base (to ensure independence between samples). Data from strain carrying human YAC 1 (left panel) and human YAC 2 (right panel) are shown as subplots. nEvolved = 12054 for both strains, and nnaïve = 760 for human YAC 1 and nnaïve = 811 for human YAC 2. Plots include all bases.
